Catherine Limperopoulos, Ph.D. Director & Chief
Catherine Limperopoulos, Ph.D., is Center Director of Prenatal, Neonatal & Maternal Health Research and Director & Chief of the Developing Brain Institute (DBI) at Children’s National. Dr. Limperopoulos is also (tenured) Professor of Radiology, Neurology and Pediatrics and Professor of Obstetrics and Gynecology at the George Washington University (GWU) School of Medicine & Health Sciences.Dr. Limperopoulos studies the causes and consequences of adverse prenatal environments and
brain and placental development in high-risk fetal, preterm and infant populations. As Center Director, she continues to develop novel tools and precision medicine solutions to diseases that have their origins in the womb but don’t fully manifest until adulthood. Central to her research is applying advanced magnetic resonance imaging (MRI) techniques to identify important biomarkers and to better elucidate the timing and evolution of impaired brain maturation, as well as the brain’s adaptive responses. Her lab leads the world in applying advanced imaging techniques to identify early brain and placental biomarkers of risk and resilience for neurodevelopmental impairment. Her goal is to develop early and reliable signals that can identify the high-risk fetus prior to irreversible brain injury. Dr. Limperopoulos also leads the Clark Parent & Child Network Prenatal-Neonatal Pillar, a project that links parents to needed resources and time-sensitive mental health support. The Network was underwritten by a transformational, $36 million investment. And powered by that funding, the DC Mother-Baby Wellness program she oversees has received over 1,900 referrals since its inception. She also was named the A. James & Alice B. Clark Foundation Distinguished Professor of Maternal-Infant Health, an appointment that honors her unique achievements and that supports her groundbreaking research to improve the lives of children and families.
DBI has assembled leading scientists and healthcare providers from across myriad disciplines and healthcare models (tertiary care to primary care) that are at the forefront of clinical research and translational efforts focused on accelerating screening, diagnosing, treating and preventing prenatal onset brain disorders to improve child health and well-being for life. She is an occupational therapist and pediatric neuroscientist who has demonstrated repeated successes in completing novel, patient-centered clinical and translational research in uncomplicated and high-risk pregnant women and neurodiagnostic and neurodevelopmental surveillance in high-risk fetuses and preterm infants. In addition to funding from private donors, like the Clark Foundation, she has or has had funding from the National Institutes of Health (NIH), Canadian Institutes of Health Research, the Department of Defense, Patient-Centered Outcomes Research Institute and the Centers for Disease Control and Prevention. She has authored more than 170 peer-reviewed publications. She also leads the Integrating Special Populations Module of the Children’s National/GWU NIH Clinical and Translational Science Award, which focuses on improving recruitment and retention of disadvantaged women into preventive maternal-fetal clinical trials aimed at optimizing long-term, maternal-infant health and well-being.
Dr. Limperopoulos is founder and director of the DC Perinatal Consortium, which brings together multiple stakeholders from our regional (Washington, D.C.) healthcare partners in obstetrics, psychiatry and pediatrics, and an established community advisory board with representation from low-income Black communities, including the DC Primary Care Association, Mary’s Center, Community of Hope, Unity Health Care, Mamatoto Village and Black patients, representatives with expertise in advocacy and policy. The overarching mission of this DC collaborative is to determine optimal delivery of screening and low-cost interventions aimed at reducing the striking health disparities experienced by women of color in the District of Columbia.
Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab
Research, Education and Innovation Week awards
Hui SCN, Ngwa J, Kapse K, Andescavage N, Limperopoulos C. "Brain Metabolites in Neonates of Mothers With COVID-19 Infection During Pregnancy" Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025. (Certificate of Excellence awarded to lead author, Steve Hui, Ph.D. Basic & Translational Research Award. Career Level: Faculty.)
Kocher K, Ngwa J, Galla JT, Basu SK, Ottolini K, Andescavage N, du Plessis A, Limperopoulos C. "Early epigenetic biomarkers of accelerated aging in extremely versus very preterm infants." Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024. (Certificate of Excellence awarded to lead author, Kristen Kocher. Basic Science: Fellow Award.)
Ottolini K, Ngwa J, Basu S, Kapse K, Cook KM, Wu Y, Murnick J, du Plessis AJ, Andescavage N, Limperopoulos C. “Impaired Ex Utero Brain Growth of Preterm Infants Compared to In Utero Healthy Fetuses.” Oral Abstract. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Wu Y, Niforatos-Andescavage N, Wisner KL, Kapse K, Araki S, Mastracchio CE, Teramoto H, Kasper ML, du Plessis AJ, Limperopoulos C. "Prenatal SSRI exposure is associated with reduced regional fetal brain growth and cortical folding." Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024. (Certificate of Excellence awarded to lead author, Yao Wu. Clinical research: Career-Level Faculty Award.)
Recent publications & presentations
2026 | May
Elsaid NM, Twohy K, Surapaneni K, Ngwa JS, Kapse K, Andescavage N, Limperopoulos C. "Brain Microstructural Maturation in Preterm Infants Follows Distinct Trajectories Based on Brain Injury Severity." Digital Poster. 2026 ISMRM & ISMRT Annual Meeting & Exhibition. Cape Town, South Africa. May 2026.
Elsaid NM, Andescavage N, Kapse K, Limperopoulos C. "Diffusion Tensor MRI Thermometry in Preterm Neonates: Validation of a CSF-Based Model Toward Fetal Temperature Estimation." Digital Poster. 2026 ISMRM & ISMRT Annual Meeting & Exhibition. Cape Town, South Africa. May 2026.
Elsaid NM, Zhuo J, Kapse K, Twohy K, Andescavage N, Limperopoulos C. "Robust Acquisition and Processing for Diffusion Tensor Imaging of the Moving Fetus." PowerPitch Oral Presentation. 2026 ISMRM & ISMRT Annual Meeting & Exhibition. Cape Town, South Africa. May 2026.
Hui SCN, Andescavage N, Kapse K, Saleh MG, Edden RAE, Limperopoulos C. "GABA Measurements With and Without Macromolecule Suppression in the Neonatal Brain." Digital Poster. 2026 ISMRM & ISMRT Annual Meeting & Exhibition. Cape Town, South Africa. May 2026.
Jang MJ, Dimov AV, Murnick J, Choudhury TA, Liang Q, Kapse K, Kapse A, RoyChoudhury A, Yap V, Donofrio MT, Srinivasan R, Chiang G, Wang Y, Limperopoulos C, Zun Z. "Postoperative Brain Alterations in Newborns With Congenital Heart Disease Assessed by Source-Separated Magnetic Susceptibility." Digital Poster. 2026 ISMRM & ISMRT Annual Meeting & Exhibition. Cape Town, South Africa. May 2026.
2026 | April
Basu S, Govindan RB, Kapse K, du Plessis AJ, Ottolini K, Murnick J, Ngwa J, Limperopoulos C. “Active Sleep During Extrauterine Third Trimester Is Associated With Neurophysiologic Maturation in Preterm Infants.” Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Basu S, Govindan RB, Kapse K, du Plessis AJ, Ottolini K, Murnick J, Ngwa J, Limperopoulos C. “Active Sleep During Extrauterine Third Trimester Is Positively Associated With Brain White Matter Volume in Preterm Infants.” Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Cook KM, De Asis-Cruz J, Murnick J, Ottolini K, Basu S, Andescavage N, du Plessis AJ, Limperopoulos C. “Maturation of Functional Brain Connectivity in Preterm Infants Differs From Fetal Development and Based on Age at Birth.” Oral abstract. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Damera S, Andescavage N, Limperopoulos C. “Fetal Brain Shape Predicts Gestational Age and Early Dysmaturation in Congenital Heart Disease.” Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Damera S, Andescavage N, Limperopoulos C. “Fetal Subplate Dysmaturation Predicts Early Motor Outcomes in Congenital Heart Disease.” Oral abstract. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
De Asis-Cruz J, Wu Y, Kim DY, Kapse K, Merhar SL, Bann CM, Newman JE, Mack N, DeMauro SB, Ambalavanan N, Lorch SA, Wilson-Costello D, Poindexter BB, Peralta-Carcelen M, Davis JM, Limperopoulos C. “The Newborn Connectome in Antenatal Opioid Exposure.” 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Donnellan E, Ngwa JS, Liggett MO, Andescavage N, Limperopoulos C, du Plessis AJ, Govindan RB. “Neurobehavioral Stress Linked to the Central Nervous System Is Associated With Heart Rate Variability Differences in Preterm Infants.” Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Hoover G, Ottolini KM, Cook KM, Basu S, Aokalani MC, Andescavage N, Limperopoulos C. “Social Drivers of Parental Bedside Presence and Mother's Own Milk Provision for Preterm Infants in the Neonatal Intensive Care Unit.” Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Kim JH, De Asis-Cruz J, Kapse K, Wu Y, Merhar SL, Bann CM, Newman JE, Mack N, DeMauro SB, Ambalavanan N, Lorch SA, Wilson-Costello D, Poindexter BB, Peralta-Carcelen M, Davis JM, Limperopoulos C. "Nonlinear Brain Network Disruption in Opioid-Exposed Neonates Revealed by Deep Generative Modeling." Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Mack N, Divaris K, Bann CM, Newman JE, DeMauro S, Ambalavanan N, Lorch SA, Wilson-Costello D, Poindexter B, Peralta-Carcelen M, Davis JM, Limperopoulos C, Merhar SL. "Early Childhood Caries Risk Factors Differ Between Children With Prenatal Opioid Exposure and Unexposed Controls." 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Ottolini K, Ngwa J, Basu S, Kapse K, Cook KM, Wu Y, Murnick J, du Plessis AJ, Andescavage N, Limperopoulos C. “Impaired Ex Utero Brain Growth of Preterm Infants Compared to In Utero Healthy Fetuses.” Oral Abstract. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Ottolini K, Chirumamilla VC, Basu S, Andescavage N, Ngwa J, du Plessis AJ, Limperopoulos C, Govindan R. “Nutritional Factors Associated With Autonomic Nervous System Maturation in Preterm Infants.” Oral Abstract. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Stage A, Hui SCN, Kapse K, Andescavage N, Ottolini K, Basu S, Ngwa J, Murnick J, Limperopoulos C. "Relationship of Clinical Co-Morbidities With the Altered Maturational Trajectory of Cerebral Metabolites in Preterm Infant.” Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Wu Y, De Asis-Cruz J, Kapse K, Merhar SL, Bann CM, Newman JE, Davis JM, Ambalavanan N, De Mauro SB, Lorch SA, Wilson-Costello D, Poindexter BB, Mack N, Peralta-Carcelen M, Limperopoulos C. "Associations Between Maternal Mental Health and Amygdala and Hippocampus Volumes in Newborns With Antenatal Opioid Exposure." Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Wu Y, Merhar SL, Bann CM, Newman JE, Kapse K, De Asis-Cruz J, Davis JM, Ambalavanan N, De Mauro SB, Lorch SA, Wilson-Costello D, Poindexter BB, Mack N, Peralta-Carcelen M, Limperopoulos C. "Neonatal Brain Volumes Differ Across Neurobehavioral Profiles and Vary by Antenatal Opioid Exposure." Poster presentation. 97th Pediatric Academic Societies Meeting. Boston, MA. April 2026.
Hoover G, Ottolini KM, Cook KM, Aokalani MC, Andescavage N, Limperopoulos C. “Analysis of Mother's Own Milk Provision and Parental Presence in NICU Settings Using the Social Vulnerability Index.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Kim DY, Murnick J, Kim JH, Kapse K, De Asis-Cruz J, Limperopoulos C. “Attention-Augmented ResNet for Fetal Brain-Age Estimation: Application to Brain-Age Gap Prediction in Congenital Heart Disease.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Ottolini KM, Ngwa JS, Basu SK, Kapse K, Cook KM, Wu Y, Murnick J, du Plessis AJ, Andescavage N, Limperopoulos C. “Impaired ex Utero Brain Growth of Preterm Infants Compared to in Utero Healthy Fetuses.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Twohy K, Elsaid NMH, Limperopoulos C, Andescavage N. “Structural Assessment of the ex Vivo Placenta Using Magnetic Resonance Elastography.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Beilfuss AM, Andescavage N, Ottolini KM, Limperopoulos C, Latif H, Pen R. “Maternal Mental Health and Breastmilk Composition in Mothers of Preterm Infants.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Cook KM, De Asis-Cruz J, Murnick J, Ottolini KM, Basu SK, Andescavage N, du Plessis AJ, Limperopoulos C. “Prematurely Born Infants Exhibit Atypical Functional Brain Development Compared to Fetal Peers and Degree of Prematurity.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Donnellan E, Aokalani MC, Ilori F, Andescavage N, Limperopoulos C. “Exploratory Factor Analysis of the 14-Item Parental Stressor Scale: Neonatal Intensive Care Unit.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Gothelf I, Andescavage N, Limperopoulos C, Kushal K, Pen RG, Liszka L, Widener BR, Cook KM. “Neighborhood Disadvantage Is Associated With Occupational Therapy Uptake in the NICU and Brain Volume Changes by Term Age.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Haley R, Weiner S, Adegbulugbe E, Henderson D, Andescavage N, Limperopoulos C. “Resilience as a Moderator Between COVID-19 -Related Distress and Prenatal Anxiety During the Pandemic.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Harris J, Cook KM, Pen R, Zeman A, Andescavage N, Limperopoulos C. “Opioid Exposure in the Neonatal Intensive Care Unit Is Associated With Reduced Amygdala and Hippocampal Volumes.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Hui SCN, Andescavage N, Kapse K, Limperopoulos C. “Brain Metabolite Changes in Fetuses of Mother With Maternal Psychological Distress.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Hui SCN, Andescavage N, Kapse K, Saleh MG, Edden RAE, Limperopoulos C. “GABA Measurements in the Neonatal Brain With and Without Macromolecule Suppression.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Hui SCN, Murali-Manohar S, Andescavage N, Kapse K, Edden RAE, Limperopoulos C. “Measures of Metabolite T2 Relaxation Times in the Fetal Brain at 3 Tesla.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Stage AJ, Hui SCN, Ottolini KM, Ngwa J, Murnick J, Basu SK, Kapse K, Andescavage N, Limperopoulos C. “Relationship Between Clinical Comorbidities and Cerebral Metabolic Maturation in Preterm Infants.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Liszka L, Andescavage N, Limperopoulos C, Liggett M, Christoffel K. “Exploring Neurobehavioral Outcomes Between Infants of Diabetic Mothers and Full-Term Controls.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Mora Álvarez MG, Cruz J, Kapse K, Vezina G, Donofrio MT, Andescavage N, Limperopoulos C. “Enlarged CSF Spaces Are Associated With Impaired Glymphatic Function in Neonates with Congenital Heart Disease.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
Ottolini KM, Chirumamilla VC, Basu SK, Andescavage N, Ngwa JS, du Plessis AJ, Limperopoulos C, Govindan RB. “Nutritional Factors Associated With Autonomic Nervous System Maturation in Preterm Infants.” Poster. Research, Education & Innovation Week 2026. Washington, D.C. April 2026.
2026 | March
Elsaid NHM, Andescavage N, Limperopoulos C. “Estimation of Fetal Temperature Using Diffusion MRI-Based Thermometry in the Amniotic Fluid.” Traditional Poster. ISMRM Workshop on Unlocking the Potential of Prenatal MRI: Advances in Fetal Brain, Heart & Placenta Imaging. Washington, D.C. March 2026.
Hui SCN, Kapse K, Andescavage N, Limperopoulos C. “Metabolite T2 Relaxation Times in the Fetal Brain at 3.0 Tesla.” Traditional Poster. ISMRM Workshop on Unlocking the Potential of Prenatal MRI: Advances in Fetal Brain, Heart & Placenta Imaging. Washington, D.C. March 2026.
Hui SCN, Andescavage N, Limperopoulos C. “The Impact of Prenatal Maternal Psychological Distress on Brain Metabolites in the Fetal Brain.” Traditional Poster. ISMRM Workshop on Unlocking the Potential of Prenatal MRI: Advances in Fetal Brain, Heart & Placenta Imaging. Washington, D.C. March 2026.
Kim DY, Murnick J, Kim JH, Kapse K, De Asis-Cruz J, Limperopoulos C. “Attention-Augmented ResNet for Fetal Brain-Age Gap Estimation in Congenital Heart Disease Across Ventricular Physiologies.” Oral Presentation. ISMRM Workshop on Unlocking the Potential of Prenatal MRI: Advances in Fetal Brain, Heart & Placenta Imaging. Washington, D.C. March 2026.
Limperopoulos C. “Translating Novel Prenatal Imaging Methods Into Better Outcomes for Patients With CHD.” Oral Presentation. ISMRM Workshop on Unlocking the Potential of Prenatal MRI: Advances in Fetal Brain, Heart & Placenta Imaging. Washington, D.C. March 2026.
Mora Álvarez MG, De Asis-Cruz J, Kapse K, Vezina G, Donofrio MT, Andescavage N, Limperopoulos C. “Non-Invasive MRI Biomarkers of Impaired Glymphatic Function in Neonates With Congenital Heart Disease.” Oral Presentation. ISMRM Workshop on Unlocking the Potential of Prenatal MRI: Advances in Fetal Brain, Heart & Placenta Imaging. Washington, D.C. March 2026.
Twohy K, Elsaid NMH, Andescavage N, Limperopoulos C. “Mapping Mechanical Properties of the ex Vivo Human Placenta Using Magnetic Resonance Elastography.” Oral Presentation. ISMRM Workshop on Unlocking the Potential of Prenatal MRI: Advances in Fetal Brain, Heart & Placenta Imaging. Washington, D.C. March 2026.
Leonard A, Chow M, Rasmussen J, Madan N, Salih K, Kapse K, Limperopoulos C, Davis JM, De Asis-Cruz J*, Yen E* (*co-senior authors). “Brain-Growth Connection: Impact of Maternal Opioid Use on Neonatal Hypothalamic Changes and Anthropometric Measurements.” Oral Presentation. Eastern Society for Pediatric Research (ESPR) 2026 Annual Conference. Philadelphia, PA March 2026.
2026 | February
Liszka L, Andescavage A, Christoffel K, Liggett MO, Limperopoulos C.“Exploring Neurobehavioral Outcomes Between Infants of Diabetic Mothers and Full-Term Controls.” Poster. 17th International Newborn Brain Conference (INBBC 2026). Naples, Italy. February 2026.
Ngwa JS, Govindan RB, Andescavage N, Basu S, Ottolini K, Kapse K, Murnick J, Limperopoulos C, du Plessis, AJ. “Heart Rate Variability Using Time and Frequency Domain Metrics Is Associated With Brain Volumes in Preterm Infants.” Poster. 17th International Newborn Brain Conference (INBBC 2026). Naples, Italy. February 2026.
Stage AJ, Hui SCN, Ottolini K, Ngwa J, Murnick J, Basu S, Kapse K, Andescavage N, Limperopoulos C. "Altered Maturational Trajectory of Cerebral Metabolites in Preterm Infants." Poster. 17th International Newborn Brain Conference (INBBC 2026). Naples, Italy. February 2026.
2026 | January
Weiner S, Wu Y, Cheng JJ, Liggett M, McCants C, Adegbulugbe E, Mears A, Henderson D, Andescavage N, Limperopoulos C. “The COVID Generation: The Neurodevelopmental Consequences of in utero COVID-19 Exposure.” Brain, Behavior, and Immunity. 2026 Jan 1:106238. doi: 10.1016/j.bbi.2025.106238. Epub ahead of print. PMID: 41483846
https://pubmed.ncbi.nlm.nih.gov/41483846
2025 | December
Ilori F, Andescavage NN, Wisner KL, Ngwa JS, Govindan RB, Limperopoulos C. “The Role of Perinatal Perceived Stress in the Setting of Adverse Childhood Experience and Perinatal Anxiety and Depressive Symptoms.” BMC Psychology. 2025 Dec 29;13(1):1384. doi: 10.1186/s40359-025-03628-6. PMID: 41462378; PMCID: PMC12751169
https://pubmed.ncbi.nlm.nih.gov/41462378
2025 | May
Alvarez MM, Limperopoulos C, De Asis-Cruz J. "Diffusion Tensor Imaging for Evaluating Glymphatic System Function in Neonates With Complex Congenital Heart Disease" Digital Poster. 2025 ISMRM & ISMRT Annual Meeting & Exhibition. Honolulu, Hawaii. May 2025.
Cook KM, De Asis-Cruz J, Andescavage N, Limperopoulos C. “Perinatal Pain and Opioid Exposure in Preterm Infants Alters Brain Connectivity.” Paper Symposium Presentation. Society for Research in Child Development (SRCD) 2025 Biennial Meeting. Minneapolis, MN. May 2025.
Elsaid NM, et al. "Measuring Perfusion in Normal and Pathological Placentas Using an Advanced IVIM Method." Poster. 2025 ISMRM & ISMRT Annual Meeting & Exhibition. Honolulu, Hawaii. May 2025.
Hui SCN, et al. “Brain Metabolite Concentrations in Neonates of Mothers With COVID-19 Exposure During Pregnancy: A Case-Control Study." Digital Poster. 2025 ISMRM & ISMRT Annual Meeting & Exhibition. Honolulu, Hawaii. May 2025.
2025 | April
Jacobwitz M, Kapse K, Ngwa J, De Asis-Cruz J, Wu Y, Donofrio MT, McDermott C, du Plessis A, Limperopoulos C, Andescavage N. “Placental and Fetal In Utero Growth Among Fetuses With Congenital Heart Disease.” JAMA Network Open. 2025 Apr 1;8(4):e257217. doi: 10.1001/jamanetworkopen.2025.7217. PMID: 40272798; PMCID: PMC12022807
https://pubmed.ncbi.nlm.nih.gov/40272798
Kim JH, De Asis-Cruz J, Cook KM, Limperopoulos C. “Evaluating the Effects of Volume Censoring on Fetal Functional Connectivity.” Scientific Reports. 2025 Apr 16;15(1):13181. doi: 10.1038/s41598-025-96538-x. PMID: 40240427
https://pubmed.ncbi.nlm.nih.gov/40240427/
Wu Y*, Merhar SL*, Bann CM, Newman JE, Kapse K, De Asis-Cruz J, Mack N, De Mauro SB, Ambalavanan N, Davis JM, Lorch SA, Wilson-Costello D, Poindexter BB, Peralta-Carcelen M, Limperopoulos C. “Antenatal Opioid Exposure and Global and Regional Brain Volumes in Newborns.” JAMA Pediatrics. Published online April 7, 2025. (* Drs. Wu and Merhar contributed equally to this work.)
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2832261
Cook KM, De Asis-Cruz J, McDermott C, Andescavage N, Limperopoulos C. "Experience of Neighborhood Disadvantage Is Associated With Altered Structural Brain Development Even Before Birth" Oral abstract presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii.
Damera SR, Wu Y, De Asis-Cruz J, Andescavage N, Limperopoulos C. "Tensor-Based Morphometry Identifies Impaired Growth of Novel Brain Areas in Fetuses With Congenital Heart Disease." Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
De Asis-Cruz J, Merhar SL, Kapse K, Wu Y, Bann CM, Newman JE, Mack N, DeMauro SB, Ambalavanan N, Lorch SA, Wilson-Costello D, Poindexter BB, Peralta Carcelen M, Davis JM, Limperopoulos C. "Brain Functional Connectivity Correlates With Neurobehavioral Impairments in Opioid-Exposed Neonates." Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
De Asis-Cruz J, Mora Alvarez MG, Kalsi A, Kapse K, McDermott CE, Vezina G, Donofrio MT, Limperopoulos C. “Disrupted Preoperative White Matter Brain Microstructure in Newborns With Complex Congenital Heart Disease.” Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
De Asis-Cruz J, Mulkey SB, Kapse K, Wu Y, Teramoto H, Mora Álvarez MG, Andringa-Seed R, Arroyave-Wessel M, Berl M, Tarud R, Vezina G, Cure C, Limperopoulos C. "Disrupted Ventral Striatal Functional Connectivity in Colombian School-Age Children Exposed in Utero to the Zika Virus." Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii.
Henderson D, Andescavage N, Keller JM, Bassa MM, Adegbulugbe E, Brechot C, Le NH, Limperopoulos C. "Mommy&Me: Enrolling Black Moms and Babies in Clinical Research" Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
Hui SCN, Ngwa JS, Kapse K, Andescavage N, Limperopoulos C. "Brain Metabolite Concentrations in Neonates of Mothers With COVID-19 Exposure During Pregnancy: A Case-Control Study." Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
Kalsi A, Kapse K, Vezina G, Donofrio M, Limperopoulos C, De Asis-Cruz J. “Disrupted Preoperative White Matter Brain Microstructure in Newborns with Complex Congenital Heart Disease” Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii.
Kim JH, Tripathi A, Limperopoulos C, De Asis-Cruz J. "Optimizing Hyperparameters of U-Net-Based Brain Segmentation Algorithms for Late 2nd and Early 3rd Trimester Fetuses." Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
Mora Álvarez MG, Mulkey SB, Kapse K, Wu Y, Teramoto H, Andringa-Seed R, Arroyave-Wessel M, Berl MM, Tarud Sabbag RE, Vezina G, Cure C, De Asis-Cruz J, Limperopoulos C. "White Matter Microstructural Disruptions in Zika Virus-Exposed Children Without Congenital Zika Syndrome." Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
Weiner S, Cheng JJ, Wu Y, Liggett M, McCants C, Adegbulugbe E, Mears A, Henderson D, Limperopoulos C, Andescavage N. "Neonatal Hippocampal Volumes Are Associated With Toddler Behavior in Children Born During the COVID-19 Pandemic" High-scoring oral abstract. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
Wu Y, Kapse K, Andringa-Seed R, Arroyave-Wessel M, Berl MM, Cure C, Teramoto H, De Asis-Cruz J, Mora Álvarez MG, Vezina G, Tarud Sabbag RE, Limperopoulos C, Mulkey SB. "Reduced Brain Volumes in Normocephalic Children With Prenatal Zika Virus Exposure." Oral abstract presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii.
Yen E, Leonard A, Chow M, Kapse K, Salih K, Singh K, Davis J, Limperopoulos C, De-Asis Cruz J. “Characteristics of Maternal Opioid Use and Early Brain Changes in Offspring.” Poster presentation. Pediatric Academic Societies 2025. Honolulu, Hawaii. April 2025.
Amick J, Liggett M, Limperopoulos C, Andescavage N. "Assessing Neonatal Neurobehavior: Detailed Comparison of the NICU Network Neurobehavioral Scale With the NeoNatal Neurobehavioral Scale-II" Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Canfield A, Cook KM, Andescavage N, Limperopoulos C. “Therapeutic Opioid Exposure in the NICU Is Associated With Changes in Structural Brain Development in a Sex-Dependent Manner” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Cook KM, De Asis-Cruz J, McDermott C, Andescavage N, Limperopoulos C. “Alterations in Fetal Brain Volumes Are Associated With Degree of Neighborhood Disadvantage” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Dampha MS, Chafin M, Saleem N, Etienne S, Henderson D, Le HN, Andescavage N, Limperopoulos C. “The Role of Patient Navigation in Addressing Basic Needs in Low-Income Black Perinatal Individuals in DC” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Donnellan EL, Govindan RB, Ngwa JS, Andescavage N, Limperopoulos C, du Plessis AJ. “Is Heart Rate Variability Associated With Neurobehavior in Preterm Infants?” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Elsaid NMH, Tagare HD, Ngwa JS, Kapse K, Limperopoulos C, Andescavage N. “Measuring Perfusion in Normal and Pathological Placentas Using an Advanced IVIM Method” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Kim JH, De Asis-Cruz J, Andescavage NN, du Plessis AJ, McDermott C, Limperopoulos C. “Disrupted Motor Networks in Neonates With Complex Congenital Heart Disease” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Kocher K, Ottolini K, Ngwa J, Latif H, du Plessis AJ, Limperopoulos C, Andescavage N. “Preterm Infants Experiencing Extrauterine Growth Failure Exhibit Epigenetic Age Deacceleration” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Mora Álvarez MG, De Asis-Cruz J, Kapse K, Vezina G, Donofrio MT, Limperopoulos C. “Diffusion Tensor Imaging for Evaluating Glymphatic System Function in Neonates with Complex Congenital Heart Disease” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Ngwa JS, Govindan R, Galla J, Kapse K, Basu S, Andescavage N, du Plessis AJ, Limperopoulos C. “Leveraging Autonomic Cardiorespiratory Measures to Predict Total Brain Volumes in Preterm Infants” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Ottolini KM, Andescavage N, Basu SK, Zeman A, du Plessis AJ, Limperopoulos C. "Maternal NICU Presence and Milk Provision at Discharge in Preterm Infants" Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Ramlogan A, Bartolini E, Kohrt B, Andescavage N, du Plessis AJ, Limperopoulos C. “Prenatal and Postnatal Mental Health of Caregivers of Infants Requiring NICU Admissions” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Stage A, Ottolini K, Hui SCN, Ngwa J, Zeman A, Murnick J, Basu S, Kapse K, Andescavage N, Limperopoulos C. "Altered Maturational Trajectory of Cerebral Metabolites in Preterm Infants" Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Wambach C, De Asis-Cruz J, Weiner S, Kim JH, Kapse K, Limperopoulos C, Andescavage N. "Prenatal Maternal Psychological Distress and Functional Brain Development in Neonates" Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Weiner S, Cheng JJ, Wu Y, Liggett M, McCants C, Adegbulugbe E, Mears A, Henderson D, Andescavage N, Limperopoulos C. “Maternal Stress and Anxiety: The Connective Thread Between Infant Brain Development and Toddler Social-Emotional Behavior” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Weiner S, Wu Y, Liggett M, McCants C, Adegbulugbe E, Mears A, Henderson D, Andescavage N, Limperopoulos C. “Neurodevelopmental Consequences of In Utero COVID-19 Exposure” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Weiner S, Wu Y, Liggett M, McCants C, Adegbulugbe E, Mears A, Henderson D, Andescavage N, Limperopoulos C. “Newborn Brain As the Basis of Early Childhood Development in a Normative Healthy Cohort” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Wu Y, Merhar SL, Bann C, Newman JE, Kapse K, De Asis-Cruz J, Mack N, De Mauro SB, Ambalavanan N, Davis JM, Lorch S, Wilson-Costello DE, Poindexter B, Peralta-Carcelan M, Limperopoulos C. “Antenatal Opioid Exposure Is Associated With Reduced Global and Regional Brain Volumes in Newborns” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025
Wu Y, Andescavage N, Liggett M, Ngwa JS, Kapse A, Kapse K, McDermott CE, Donofrio MT, Wisner KL, Wessel D, du Plessis AJ, Limperopoulos C. “Elevated Prenatal Maternal Psychological Distress Is Associated With Impaired Neurodevelopment in Toddlers With Congenital Heart Disease” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Wu Y, Merhar SL, Bann C, Newman JE, Kapse K, Asis-Cruz JD, Mack N, De Mauro SB, Ambalavanan N, Davis JM, Lorch S, Wilson-Costello DE, Poindexter B, Peralta-Carcelan M, Limperopoulos C. “Impaired Cerebral Cortical Maturation in Newborns Exposed to Antenatal Opioids” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Wu Y, Merhar SL, Bann C, Newman JE, Kapse K, Asis-Cruz JD, Mack N, De Mauro SB, Ambalavanan N, Davis JM, Lorch S, Wilson-Costello DE, Poindexter B, Peralta-Carcelan M, Limperopoulos C. “Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome (NOWS) Is Associated With Smaller Neonatal Brain Volumes” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
2025 | March
Henderson D, Andescavage N, Keller JM, Bassa MM, Adegbulugbe E, Brechot C, Le NH, Limperopoulos C. "Mommy&Me: Enrolling Black Moms and Babies in Clinical Research." Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
Mora Álvarez M, Mulkey S, Kapse K, Wu Y, Teramoto H, Andringa-Seed R, Arroyave-Wessel M, Berl M, Tarud Sabbag RE, Vezina G, Cure C, De Asis-Cruz J, Limperopoulos C. "White Matter Microstructural Disruptions in Zika Virus-Exposed Children Without Congenital Zika Syndrome.” Poster presentation. Children’s National Hospital 15th Annual Research, Education and Innovation Week. Washington, D.C. March-April 2025.
2025 | February
Le HN, Andescavage N, Keller JM, Bassa MM, Danielson AL, Henderson D, Bond S, Mjenga N, Wells S, Quinn P, Limperopoulos C. “Protocol for a Randomized Controlled Trial of the Mommy&Me Study: A Multi-Modal Approach to Address Social Determinants of Health and Mental Health Among Low-Income Black Perinatal Populations.” SSRN. 2025 Feb. 13. Epub.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5122551
2025 | January
Christoffel K, De Asis Cruz J, Cook KM, Kapse K, Andescavage N, Basu S, Limperopoulos C, du Plessis A. “Third Trimester Development of Central Autonomic Network Connectivity Is Altered in an Extrauterine Environment.” Neonatology. 2025 Jan 2:1-20. doi: 10.1159/000543277. Epub ahead of print. PMID: 39746339
https://pubmed.ncbi.nlm.nih.gov/39746339