STEVE C.N. HUI, PH.D. Research Faculty (Assistant Professor)

Steve C.N. Hui, Ph.D., is a research faculty (assistant professor) in the Developing Brain Institute (DBI) at Children’s National Hospital. Steve’s research interests lie in the application and development of new sequences for brain magnetic resonance (MR) spectroscopy.

Prior joining DBI, he completed his postdoctoral fellowship at the Johns Hopkins University School of Medicine. Steve has participated in the HEALthy Brain and Child Development (HBCD) study, a large National Institutes of Health-funded study of early-childhood brain development involving 25 sites around the U.S. He also was involved in other collaborative studies, including the investigation of frequency drift, which included 80 participating sites, using over 100 3T MR scanners from three major

Preferred Steve CN Hui no background

vendors; and another study that investigated the relationship between age and macromolecular concentrations. Steve also has developed the MRSCloud, a cloud-based platform for generating metabolite basis sets for linear-combination modeling analyses, which aims to help community users to acquire basis sets in a reliable and convenient manner.

Steve completed his M.Sc. and Ph.D. studies at the Chinese University of Hong Kong. During his postgraduate training, he focused on the development of an automated algorithm for lipid segmentation using MR imaging, and he studied the etiology of non-alcoholic fatty liver disease using MR spectroscopy. He obtained his bachelor’s degree in Applied Science at the University of British Columbia.

Address: 111 Michigan Ave NW, Washington, DC 20010
Email: [email protected]
Department: MRI Lab

Recent publications & presentations

2024 | July

Chiyanika C, Hui SCN, Sin DMC, Shumbayawonda E, Wong SKH, Ng EKW, Yip TCF, Wong VWS, Chu WCW. “The effectiveness of magnetic resonance imaging (MRI) iron corrected T1 in monitoring metabolic dysfunction-associated steatohepatitis in obesity following bariatric surgery and lifestyle modification: a prospective cohort study.” Quantitative Imaging in Medicine and Surgery. 2024 Jul 1; 14 (7)
https://qims.amegroups.org/article/view/124854

2024 | June

Hui SCN, Murali-Manohar S, Zöllner HJ, Hupfeld KE, Davies-Jenkins CW, Gudmundson AT, Song Y, Yedavalli V, Wisnowski JL, Gagoski B, Oeltzschner G, Edden RAE. “Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for advanced MRS.” Journal of Neuroscience Methods. 2024 Jun 26;409:110206. doi: 10.1016/j.jneumeth.2024.110206. Epub ahead of print. PMID: 38942238
https://pubmed.ncbi.nlm.nih.gov/38942238

2024 | May

Basu S, Hui SCN, Kapse K, Saulino P, Carney H, Galla J, Andescavage N, Murnick J, du Plessis A, Limperopoulos C. Cerebellar GABA and glutamate concentrations at term-equivalent age predicts 18-month cognitive deficits in preterm infants. Pediatric Academic Societies 2024. Toronto. May 2024.

Hui SCN, Kapse K, Kasper M, Saulino P, Limperopoulos C, Andescavage N. Brain metabolite concentrations in neonates of diabetic mothers. Pediatric Academic Societies 2024. Toronto. May 2024.

Hui SCN, Andescavage N, Ngwa JS, Kapse K1, Kasper M, Saulino P, Limperopoulos C. Brain metabolite concentrations in neonates with congenital heart disease before and after cardiac surgery. ISMRM & SMRT Annual Meeting & Exhibition. Singapore. May 2024.

Murali-Manohar S, Zöllner HJ, Davies-Jenkins C, Gudmundson AT, Hui SCN, Song Y, Gagoski B, Tisdall D, Saleh MG, Weldon KB, Rosenberg JT, Noeske R, Clarke WT, Oeltzschner G, Wisnowski JL, Edden RAE. Edited MRS of the infant brain at 28 sites. ISMRM & SMRT Annual Meeting & Exhibition. Singapore. May 2024.

Song Y, Zöllner HJ, Davies-Jenkins CW, Hupfeld KE, Gudmundson AT, Hui SCN, Ratnanather T, Oeltzschner G, Dean III DC, Ceritoglu C, Edden RAE. A water relaxometry atlas for tissue correction of MRS data. ISMRM & SMRT Annual Meeting & Exhibition. Singapore. May 2024.

Stefanovski D, Hui SCN, Barker P, Kamel I, Zemel B, Kelly A, Magge SN, Greater liver fat is associated with divergent metabolic responses among South Asian, White, and African American youth without diabetes. Pediatric Endocrine Society Annual Meeting. Chicago, IL. May 2024.

2024 | April

Gao Y, Liu Y, Zhao S, Liu Y, Zhang C, Hui S, Mikkelsen M, Edden RAE, Meng X, Yu B, Xiao L. MRS study on the correlation between frontal GABA+/Glx ratio and abnormal cognitive function in medication-naive patients with narcolepsy. Sleep Med. 2024 Apr 6;119:1-8. doi: 10.1016/j.sleep.2024.04.004. Epub ahead of print. PMID: 38626481
https://pubmed.ncbi.nlm.nih.gov/38626481/

Murali-Manohar S, Gudmundson AT, Hupfeld KE, Zöllner HJ, Hui SCN, Song Y, Simicic D, Davies-Jenkins CW, Gong T, Wang G, Oeltzschner G, Edden RAE. Metabolite T1 relaxation times decrease across the adult lifespan. NMR Biomed. 2024 Apr 2:e5152. doi: 10.1002/nbm.5152. Epub ahead of print. PMID: 38565525
https://pubmed.ncbi.nlm.nih.gov/38565525/

Hupfeld KE, Zöllner HJ, Hui SCN, Song Y, Murali-Manohar S, Yedavalli V, Oeltzschner G, Prisciandaro JJ, Edden RAE. Impact of acquisition and modeling parameters on the test-retest reproducibility of edited GABA. NMR Biomed. 2024 Apr;37(4):e5076. doi: 10.1002/nbm.5076. Epub 2023 Dec 13. PMID: 38091628; PMCID: PMC10947947
https://pubmed.ncbi.nlm.nih.gov/38091628/

Hui S, Andescavage N, Ngwa J, Kapse K, Kasper M, Saulino P, Limperopoulos C. Brain metabolite concentrations in neonates with Congenital Heart Disease before and after cardiac surgery. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Hui S, Kapse K, Kasper M, Saulino P, Limperopoulos C, Andescavage N. Brain metabolite concentrations in neonates of diabetic mothers. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Basu S, Hui SCN, Kapse K, Galla J, Andescavage N, Murnick J, du Plessis AJ, Limperopoulos C. Cerebellar GABA and glutamate concentrations at term-age predicts cognitive deficits in preterm infants. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

2024 | March

Ehrhardt SE, Wards Y, Rideaux R, Marjańska M, Jin J, Cloos MA, Deelchand DK, Zöllner HJ, Saleh MG, Hui SCN, Ali T, Shaw TB, Barth M, Mattingley JB, Filmer HL, Dux PE. Neurochemical predictors of generalised learning induced by brain stimulation and training. J Neurosci. 2024 Mar 26:e1676232024. doi: 10.1523/JNEUROSCI.1676-23.2024. Epub ahead of print. PMID: 38531634
https://pubmed.ncbi.nlm.nih.gov/38531634/

2024 | February

Remahi S, Mabika M, Côté S, Iorio-Morin C, Near J, Hui SCN, Edden RAE, Théoret H, Whittingstall K, Lepage JF. Neurotransmitter levels in the basal ganglia are associated with intracortical circuit activity of the primary motor cortex in healthy humans. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Feb 8;129:110892. doi: 10.1016/j.pnpbp.2023.110892. Epub 2023 Nov 10. PMID: 37952692
https://pubmed.ncbi.nlm.nih.gov/37952692/

Hui SCN, Zöllner HJ, Gong T, Hupfeld KE, Gudmundson AT, Murali-Manohar S, Davies-Jenkins CW, Song Y, Chen Y, Oeltzschner G, Wang G, Edden RAE. sLASER and PRESS perform similarly at revealing metabolite-age correlations at 3 T. Magn Reson Med. 2024 Feb;91(2):431-442. doi: 10.1002/mrm.29895. Epub 2023 Oct 24. PMID: 37876339; PMCID: PMC10942734
https://pubmed.ncbi.nlm.nih.gov/37876339/

2023 | June

Murali-Manohar S, Gudmundson A, Hupfeld K, Zöllner H, Hui SCN, Song Y, Davies-Jenkins C, Gong T, Wang G, Oeltzschner G, Edden RAE. Metabolite T relaxation times differ across the adult lifespan, ISMRM & SMRT Annual Meeting & Exhibition, Toronto. June 2023.

Song Y, Hupfeld K, Davies-Jenkins C, Zöllner H, Crocetti D, Hui SCN, Yedavalli Y, Oeltzschner G Alessi N, Batschelett M, Puts N, Mostofsky S, Edden RAE. In vivo primary sensorimotor cortex glutathione does not differ in autistic children, ISMRM & SMRT Annual Meeting & Exhibition. Toronto. June 2023.