Rathinaswamy Bhavanandhan (RB) Govindan, Ph.D., MS Director of the Advanced Physiological Signals Processing Laboratory
Rathinaswamy Bhavanandhan (RB) Govindan, Ph.D., MS, is director of the Advanced Physiological Signals Processing Laboratory (APSPL) at Children’s National Hospital, overseeing the acquisition of high-quality signals, developing and maintaining automated analyses pipelines for processing these signals, and training end-users on the application of these analyses pipelines. The primary goal of APSPL research is identifying
![RB Govindan no background RB Govindan no background](https://developingbrainresearchlab.org/wp-content/uploads/2024/02/RB-Govindan-no-background.png)
antecedents of brain injury in critically ill infants through continuous monitoring and characterization of multimodal physiological signals. Dr. Govindan has experience in developing monitoring tools to acquire and process data from patients’ bedside monitors. Using proprietary software, his team has continuously collected electrocardiograms and processed heartrate variability in close to real-time for several days from 100+ infants. He also has experience in collecting and processing data using wearable sensors (e.g., Everion, Biofourmis, Boston, U.S.). Using Everion, Dr. Govindan’s team reliably has collected heart rates from nearly 200 pregnant women and mothers of newborns to understand the onset of pregnancy-related stress or postpartum depression. Dr. Govindan’s current research focus is on real-time characterization of the physiological signals to derive biomarkers that can help to make informed clinical decisions. His team has honed several signal processing routines to address the highly prevalent artifacts in the physiological signals collected in a hostile environment of critical care monitoring. He has served as a Co-investigator on several National Institutes of Health grants.
He received his Ph.D. in biomedical signal processing from the Indian Institute of Technology, Madras, Chennai, India. Recently, he received an MS degree in Biotechnology with a specialization in Bioinformatics from the University of Maryland Global Campus.
Address: 111 Michigan Ave. NW; Washington, D.C., 20010
Email: [email protected]
Department: MRI Lab
Recent publications & presentations
2024 | September
Jacobwitz M, Kapse K, Ngwa J, De Asis-Cruz J, Wu Y, Govindan R, Donofrio MT, Wessel DL, du Plessis AJ, Limperopoulos C, Andescavage A. “In-Vivo Placental Volumes and Placental Growth Trajectories are Abnormal in Fetuses with Congenital Heart Disease.” International Federation of Placental Associations 2024 Conference. Montreal, Quebec. September 2024. (NIH travel award)
2024 | April
Chirumamilla VC, Hitchings L, Mulkey SB, Anwar T, Baker R, Maxwell L, De Asis Cruz J, Kapse K, Limperopoulos C, du Plessis AJ, Govindan RB. Communications among Rich-club brain regions in term low-risk newborn EEG sources. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.
Ngwa JS, Govindan R, Galla J, Kapse K, Basu S, Andescavage N, du Plessis AJ, Limperopoulos C. The impact of conventional and high-frequency oscillatory ventilation on heart rate metrics in preterm infants. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.
Jacobwitz M, Kapse K, Ngwa J, De Asis-Cruz J, Govindan R, Donofrio MT, Wessel D, du Plessis A, Limperopoulos C, Andescavage N. In-vivo placental volumes and placental growth trajectories are abnormal in fetuses with Congenital Heart Disease. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.
2024 | February
Chirumamilla VC, Hitchings L, Mulkey SB, Anwar T, Baker R, Larry Maxwell G, De Asis-Cruz J, Kapse K, Limperopoulos C, du Plessis A, Govindan RB. Association of brain functional connectivity with neurodevelopmental outcomes in healthy full-term newborns. Clin Neurophysiol. 2024 Feb 15;160:68-74. doi: 10.1016/j.clinph.2024.02.009. Epub ahead of print. PMID: 38412745
https://pubmed.ncbi.nlm.nih.gov/38412745/
2023 | April
Rao A, Eskandar-Afshari F, Weiner Y, Billman E, McMillin A, Sella N, Roxlo T, Liu J, Leong W, Helfenbein E, Walendowski A, Muir A, Joseph A, Verma A, Ramamoorthy C, Honkanen A, Green G, Drake K, Govindan RB, Rhine W, Quan X. Clinical Study of Continuous Non-Invasive Blood Pressure Monitoring in Neonates. Sensors (Basel). 2023 Apr 2;23(7):3690. doi: 10.3390/s23073690. PMID: 37050750; PMCID: PMC10098632
https://pubmed.ncbi.nlm.nih.gov/37050750/
2023 | March
Chirumamilla VC, Hitchings L, Mulkey SB, Anwar T, Baker R, Larry Maxwell G, De Asis-Cruz J, Kapse K, Limperopoulos C, du Plessis A, Govindan RB. Functional brain network properties of healthy full-term newborns quantified by scalp and source-reconstructed EEG. Clin Neurophysiol. 2023 Mar;147:72-80. doi: 10.1016/j.clinph.2023.01.005. Epub 2023 Jan 23. PMID: 36731349; PMCID: PMC9975070
https://pubmed.ncbi.nlm.nih.gov/36731349/