ADRÉ J. DU PLESSIS, M.B.CH.B. Director of the Zickler Family Prenatal Pediatrics Institute

Adré J. du Plessis, M.B.Ch.B., directs the Zickler Family Prenatal Pediatrics Institute as well as the Prenatal-Neonatal Neurology Program at Children’s National Hospital. In addition, Dr. du Plessis is a Professor of Pediatrics and Neurology at the George Washington University School of Medicine. His expertise is in normal and abnormal development of the brain, as well as the mechanisms of injury to the immature brain.  His research focuses, in particular, on environmental factors that influence normal and abnormal

Portrait of a man in a suit and glasses.

brain development in the third trimester, both in utero and in the premature ex-utero environment. Thirty years ago, Dr. du Plessis was the founding director of the first dedicated clinical program for Neonatal (and later Fetal-Neonatal) Neurology at Boston Children’s Hospital and Harvard’s Longwood-area neonatal intensive care units. He has a strong track record of mentoring the next generation of prenatal-neonatal neurologists, as evidenced by his development of the first dedicated clinical research program for the immature brain, supported initially by philanthropic funds, subsequently by a National Institutes of Health K24 award (NS057568), and most recently by a T32 Training Award (NICHD). Since becoming Chief of Prenatal and Transitional Medicine and Director of the Zickler Family Prenatal Pediatrics Institute at Children’s National, Dr. du Plessis has overseen the development of a multidisciplinary clinical, research and training program with a unique focus on the developing brain. The Zickler Family Prenatal Pediatrics Institute is pioneering a continuum of care for children, starting in utero and across the transition from prenatal to postnatal life.

Address: 111 Michigan Ave. NW; Washington, D.C., 20010
Email: [email protected]
Department: The Zickler Family Prenatal Pediatrics Institute

Research, Education and Innovation Week 2024 awards

Kocher K, Ngwa J, Galla JT, Basu SK, Ottolini K, Andescavage N, du Plessis A, Limperopoulos C. Early epigenetic biomarkers of accelerated aging in extremely versus very preterm infants. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024. (Certificate of Excellence awarded to lead author, Kristen Kocher. Basic Science: Fellow Award.)


Wu Y, Niforatos-Andescavage N, Wisner KL, Kapse K, Araki S, Mastracchio CE, Teramoto H, Kasper ML, du Plessis AJ, Limperopoulos C. Prenatal SSRI exposure is associated with reduced regional fetal brain growth and cortical folding. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024. (Certificate of Excellence awarded to lead author, Yao Wu. Clinical research: Career-Level Faculty Award.)


 

Recent publications & Presentations

2024 | September

Kocher KM, Ngwa J, Kapse KJ, Bhattacharya S, Rossi C, Delot E, du Plessis A, Limperopoulos C, Andescavage N. Technical considerations for placental tissue processing and the subsequent impact on genome-wide DNA methylation analysis. Clinical Epigenetics. 2024 Sep 16;16(1):128. doi: 10.1186/s13148-024-01741-8. PMID: 39285447; PMCID: PMC11403961
https://pubmed.ncbi.nlm.nih.gov/39285447

Jacobwitz M, Kapse K, Ngwa J, De Asis-Cruz J, Wu Y, Govindan R, Donofrio MT, Wessel DL, du Plessis AJ, Limperopoulos C, Andescavage A. “In-Vivo Placental Volumes and Placental Growth Trajectories are Abnormal in Fetuses with Congenital Heart Disease.” International Federation of Placental Associations 2024 Conference. Montreal, Quebec. September 2024. (NIH travel award)

Jacobwitz M, Kapse K, Ngwa J, Donofrio MT, Wessel DL, du Plessis AJ, Limperopoulos C, Andescavage M. “Impaired Feto-Placental Growth in Congenital Heart Disease Detected Prenatally via Quantitative MRI.” International Federation of Placental Associations 2024 Conference. Montreal, Quebec. September 2024.

2024 | April

Andescavage N, Liggett M, McCants C, du Plessis A, Limperopoulos C. The effects of intrauterine programming: Prenatal COVID exposure and offspring outcomes. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Watson TT, Ottolini K, Basu S, Kapse K, Murnick J, Andescavage N, du Plessis A, Saulino P, Limperopoulos C. Timing and growth failure in very premature infants and implications for brain development. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Ottolini KM, Andescavage N, Basu SK, Kapse K, Watson T, Murnick J, du Plessis A, Limperopoulos C. Type of intravenous lipid emulsion affects very preterm brain development. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Chirumamilla VC, Hitchings L, Mulkey SB, Anwar T, Baker R, Maxwell L, De Asis Cruz J, Kapse K, Limperopoulos C, du Plessis AJ, Govindan RB. Communications among Rich-club brain regions in term low-risk newborn EEG sources. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Cook KM, De Asis-Cruz J, Andescavage N, Saulino P, Basu SK, du Plessis AJ, Limperopoulos C. Greater exposure to opioid pain medications in the NICU is associated with hyperconnectivity of the thalamus and cerebellum in infants born prematurely. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Kim JH, De Asis-Cruz J, Andescavage NN, du Plessis A, Limperopoulos C. Disrupted functional brain networks in neonates with congenital heart disease. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Ngwa JS, Govindan R, Galla J, Kapse K, Basu S, Andescavage N, du Plessis AJ, Limperopoulos C. The impact of conventional and high-frequency oscillatory ventilation on heart rate metrics in preterm infants. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Jacobwitz M, Kapse K, Ngwa J, De Asis-Cruz J, Govindan R, Donofrio MT, Wessel D, du Plessis A,  Limperopoulos C, Andescavage N. In-vivo placental volumes and placental growth trajectories are abnormal in fetuses with Congenital Heart Disease. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Basu S, Hui SCN, Kapse K, Galla J, Andescavage N, Murnick J, du Plessis AJ, Limperopoulos C. Cerebellar GABA and glutamate concentrations at term-age predicts cognitive deficits in preterm infants. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Spurney G, Gala J, Basu S, Ottolini K, Andescavage N, du Plessis A, Limperopoulos C. High prevalence of low dietary intake of choline in mothers of preterm infants. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

Rich C, Kapse K, Ngwa J, Galla JT, Basu S, Ottolini K, Andescavage N, du Plessis A, Limperopoulos C. Altered regional cerebral blood flow in preterm infants with patent ductus arteriosus. Children’s National Hospital 14th Annual Research, Education and Innovation Week. Washington, D.C. April 2024.

2024 | February

Chirumamilla VC, Hitchings L, Mulkey SB, Anwar T, Baker R, Larry Maxwell G, De Asis-Cruz J, Kapse K, Limperopoulos C, du Plessis A, Govindan RB. Association of brain functional connectivity with neurodevelopmental outcomes in healthy full-term newborns. Clin Neurophysiol. 2024 Feb 15;160:68-74. doi: 10.1016/j.clinph.2024.02.009. Epub ahead of print. PMID: 38412745
https://pubmed.ncbi.nlm.nih.gov/38412745/

2024 | January

Andescavage N, Lu YC, Wu Y, Kapse K, Keller J, Von Kohorn I, Afifi A, Vezina G, Henderson D, Wessel DL, du Plessis AJ, Limperopoulos C. Intrauterine exposure to SARS-CoV-2 infection and early newborn brain development. Cereb Cortex. 2024 Jan 31;34(2):bhae041. doi: 10.1093/cercor/bhae041. PMID: 38385890
https://pubmed.ncbi.nlm.nih.gov/38385890/

2023 | November

Cook KM, De Asis-Cruz J, Kim JH, Basu SK, Andescavage N, Murnick J, Spoehr E, Liggett M, du Plessis AJ, Limperopoulos C. Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits. BMC Med. 2023 Nov 14;21(1):435. doi: 10.1186/s12916-023-03141-w. PMID: 37957651
https://pubmed.ncbi.nlm.nih.gov/37957651/

De Asis-Cruz J, Andescavage N, Donofrio MT, Vezina G, Wessel D, du Plessis A, Limperopoulos C. Disrupted Functional Brain Connectome in the Fetus With Congenital Heart Disease. Circ Res. 2023 Nov 10;133(11):959-961. doi: 10.1161/CIRCRESAHA.123.323276. Epub 2023 Oct 12. PMID: 37823309
https://pubmed.ncbi.nlm.nih.gov/37823309/

Basu SK, Kapse KJ, Murnick J, Pradhan S, Spoehr E, Zhang A, Andescavage N, Nino G, du Plessis AJ, Limperopoulos C. Impact of bronchopulmonary dysplasia on brain GABA concentrations in preterm infants: Prospective cohort study. Early Hum Dev. 2023 Nov;186:105860. doi: 10.1016/j.earlhumdev.2023.105860. Epub 2023 Sep 21. PMID: 37757548
https://pubmed.ncbi.nlm.nih.gov/37757548/

2023 | October

Andescavage NN, Pradhan S, Gimovsky AC, Kapse K, Donofrio MT, Cheng JJ, Sharker Y, Wessel D, du Plessis AJ, Limperopoulos C. Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease. J Am Coll Cardiol. 2023 Oct 17;82(16):1614-1623. doi: 10.1016/j.jacc.2023.08.013. PMID: 37821172
https://pubmed.ncbi.nlm.nih.gov/37821172/

2023 | May

Whitehead MT, Limperopoulos C, Schlatterer SD, Mulkey SB, Fraser JL, du Plessis AJ. Hippocampal rotation is associated with ventricular atrial size. Pediatr Radiol. 2023 May 15. doi: 10.1007/s00247-023-05687-6. Epub ahead of print. Erratum in: Pediatr Radiol. 2023 May 27;: PMID: 37183230
https://pubmed.ncbi.nlm.nih.gov/37183230/

2023 | April

Andescavage N, Bullen T, Liggett M, Barnett SD, Kapse A, Kapse K, Ahmadzia H, Vezina G, Quistorff J, Lopez C, du Plessis A, Limperopoulos C. Impaired in vivo feto-placental development is associated with neonatal neurobehavioral outcomes. Pediatr Res. 2023 Apr;93(5):1276-1284. doi: 10.1038/s41390-022-02340-0. Epub 2022 Nov 5. PMID: 36335267; PMCID: PMC10147575
https://pubmed.ncbi.nlm.nih.gov/36335267/

2023 | March

Chirumamilla VC, Hitchings L, Mulkey SB, Anwar T, Baker R, Larry Maxwell G, De Asis-Cruz J, Kapse K, Limperopoulos C, du Plessis A, Govindan RB. Functional brain network properties of healthy full-term newborns quantified by scalp and source-reconstructed EEG. Clin Neurophysiol. 2023 Mar;147:72-80. doi: 10.1016/j.clinph.2023.01.005. Epub 2023 Jan 23. PMID: 36731349; PMCID: PMC9975070
https://pubmed.ncbi.nlm.nih.gov/36731349/

2022 | April

Wu Y, Espinosa KM, Barnett SD, Kapse A, Quistorff JL, Lopez C, Andescavage N, Pradhan S, Lu YC, Kapse K, Henderson D, Vezina G, Wessel D, du Plessis AJ, Limperopoulos C. Association of elevated maternal psychological distress, altered fetal brain, and offspring cognitive and social-emotional outcomes at 18 months. JAMA Netw Open. 2022 Apr 1;5(4):e229244. doi: 10.1001/jamanetworkopen.2022.9244. PMID: 35486403; PMCID: PMC9055453
https://pubmed.ncbi.nlm.nih.gov/35486403/

2022 | January

Limperopoulos C, Wessel DL, du Plessis AJ. Understanding the maternal-fetal environment and the birth of prenatal pediatrics. J Am Heart Assoc. 2022 Jan 11:e023807. doi: 10.1161/JAHA.121.023807. Epub ahead of print. PMID: 35014863
https://pubmed.ncbi.nlm.nih.gov/35014863/

Basu SK, Pradhan S, Barnett SD, Mikkelsen M, Kapse KJ, Murnick J, Quistorff JL, Lopez CA, du Plessis AJ, Limperopoulos C. Regional differences in gamma-aminobutyric acid and glutamate concentrations in the healthy newborn brain. AJNR Am J Neuroradiol. 2022 Jan;43(1):125-131. doi: 10.3174/ajnr.A7336. Epub 2021 Nov 11. PMID: 34764083
https://pubmed.ncbi.nlm.nih.gov/34764083/